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A Model for PH and HFpEF

April 4, 2017 at 1:35 pm

By Paul Schumacker, PhD, editor, American Journal of Respiratory Cell and Molecular Biology

Follow Dr. Schumacker on Twitter @ATSRedEditor

Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction

Pulmonary hypertension (PH) attributable to heart failure with preserved ejection (HFpEF), is increasingly recognized as a clinical complication of metabolic syndrome. In an April American Journal of Respiratory Cell and Molecular Biology article, Qingqing Meng and colleagues report on their development of a mouse model to the link between all three diseases. Using a high-fat diet, the authors induced metabolic syndrome in the mice, which exhibited “key clinical features” in patients with PH attributable to HFpEF, including “including elevated right ventricular systolic pressure and LV [left ventricular] end-diastolic pressure, preserved LV ejection fraction, and biventricular hypertrophy.” Wassim H. Fares and Naftali Kaminski wrote an accompanying editorial.

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