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Antibiotics Reverse Lung Function Decline in CF

June 6, 2017 at 8:44 am

By David Lederer, MD, MS, editor, Annals of the American Thoracic Society

Follow Dr. Lederer on Twitter @AnnalsATSEditor

Relationship of Antibiotic Treatment to Recovery after Acute FEV1 Decline in Children with Cystic Fibrosis

Wayne J. Morgan and colleagues previously found that children with acute declines in lung function were not always treated with antibiotics. In their June Annals of the American Thoracic Society article, they look at whether antibiotic treatment would make a difference. It does. In 9,875 patients, they found that antibiotic treatment as an impatient or outpatient was significantly more likely to reverse the decline. The likelihood, however, was greatest for those treated in the hospital: compared to no antibiotic treatment, the odds ratio for recovery to 90 percent of baseline FEV1 was 2.79, compared to no antibiotic treatment.  “These benefits extend across all disease stages,” the authors add, “and are especially important in patients with high lung function, who are at the greatest risk for an accelerated rate of decline in FEV1”.


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