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Does CELSR1 Play a Role in COPD Dimorphism?

March 2, 2017 at 11:39 am

By Paul Schumacker, PhD, editor, American Journal of Respiratory Cell and Molecular Biology

Follow Dr. Schumacker on Twitter @ATSRedEditor

Sex-based Genetic Association Study Identifies CELSR1 as a Possible COPD Risk Locus among Women

In what is believed to be the first genome-wide association study to examine sexually dimorphic risk factors for COPD, researchers analyzed over eight million single-nucleotide polymorphisms (SNPS) in 6,260 COPD patients and 5,269 controls who smoked. In their March American Journal of Respiratory Cell and Molecular Biology article, the authors report that the SNP rs9615358 in the fetal lung development gene CELSR1 appears more common in women (OR 1.37) than men (OR 0.90).  This finding, along with other study findings, suggests that CELSR1 “may play a role in sexually dimorphic COPD susceptibility, and suggest that this susceptibility may have developmental origins.”

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