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Does Mitochondrial Dysfunction Cause RV Dysfunction in Adults Born Premature?

May 5, 2017 at 4:11 pm

By Paul Schumacker, PhD, editor, American Journal of Respiratory Cell and Molecular Biology

Follow Dr. Schumacker on Twitter @ATSRedEditor

Postnatal Hyperoxia Exposure Durably Impairs Right Ventricular Function and Mitochondrial Biogenesis

Young adults born premature are at risk for right ventricular hypertrophy and dysfunction, but it is unclear why. In their May American Journal of Respiratory Cell and Molecular Biology article, Kara N. Goss and colleagues describe the results of study using a rat model to study the long-term effects of prematurity on the right ventricle and pulmonary vasculature. Not only did the rats demonstrate significant right ventricular hypertrophy and dysfunction similar to human studies, they also demonstrated significant chronic pulmonary hypertension.  Intriguingly, the researchers also report that “hyperoxia-exposed right ventricular cardiomyocytes demonstrated evidence of mitochondrial dysregulation and mitochondrial DNA damage, suggesting potential mitochondrial dysfunction as a cause of right ventricular dysfunction.” Vinicio A. de Jesus Perez wrote an accompanying editorial.


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