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GWAS Reveals Pneumonia Genes of Interest

January 13, 2017 at 4:55 pm

By Paul Schumacker, PhD, editor, American Journal of Respiratory Cell and Molecular Biology

Follow Dr. Schumacker on Twitter @ATSRedEditor

Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis

In their January American Journal of Respiratory Cell and Molecular Biology article, Lystra P. Hayden and colleagues present results from the first genome-wide association study of pneumonia susceptibility during childhood and over a lifetime.  Subjects included current and former smokers, with and without COPD, enrolled in the COPDGene Study. The researchers found that the prevalence of childhood pneumonia among participants was about double the prevalence in all U.S. children, which, they write, may indicate that participants were more likely to have childhood asthma or grow up in a house with a smoker, among other risk factors for pneumonia. The researchers identified potential genes associated with the risk of pneumonia, but no single nucleotide polymorphism reached genome-wide significance. The genes of interest related to lung growth and development, vascularization, lung function, and repair. Surprisingly, the authors write, in a network analysis of childhood pneumonia genes, out of 30 found to be significant, only one immune response network was implicated.

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