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HAP and CAP Host Responses Strikingly Similar

December 19, 2016 at 4:35 pm

By Jadwiga A. Wedzicha, MD, editor, American Journal of Respiratory and Critical Care Medicine

Follow Dr. Wedzicha on Twitter @ATSBlueEditor

Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients

By measuring 19 plasma markers, Lonneke A. van Vught and her European colleagues aimed to determine if the systemic host response to hospital-acquired pneumonia (HAP) differs from community-acquired pneumonia (CAP). They report in the Dec. 1 American Journal of Respiratory and Critical Care Medicine that, contrary to their hypothesis, their “analysis revealed largely similar responses, “including systemic inflammatory and cytokine responses, activation of coagulation and the vascular endothelium,” and a blood leukocyte genomic response that was more than 75 percent the same. HAP patients did, however, demonstrate a significant “under-expression of a type-1 interferon signaling gene signature,” the authors wrote, “that might contribute to increased vulnerability of hospitalized patients to less virulent respiratory pathogens.”

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