, ,

HAP and CAP Host Responses Strikingly Similar

December 19, 2016 at 4:35 pm

By Jadwiga A. Wedzicha, MD, editor, American Journal of Respiratory and Critical Care Medicine

Follow Dr. Wedzicha on Twitter @ATSBlueEditor

Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients

By measuring 19 plasma markers, Lonneke A. van Vught and her European colleagues aimed to determine if the systemic host response to hospital-acquired pneumonia (HAP) differs from community-acquired pneumonia (CAP). They report in the Dec. 1 American Journal of Respiratory and Critical Care Medicine that, contrary to their hypothesis, their “analysis revealed largely similar responses, “including systemic inflammatory and cytokine responses, activation of coagulation and the vascular endothelium,” and a blood leukocyte genomic response that was more than 75 percent the same. HAP patients did, however, demonstrate a significant “under-expression of a type-1 interferon signaling gene signature,” the authors wrote, “that might contribute to increased vulnerability of hospitalized patients to less virulent respiratory pathogens.”

AJRCCM Highlights

Dec. 1

Angiotensin-Converting Enzyme Inhibition as an Adjunct to Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease

Sources of Variation in Sweat Chloride Measurements in Cystic Fibrosis

Post-traumatic Stress Disorder, Bronchodilator Response, and Incident Asthma in World Trade Center Rescue and Recovery Workers

Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis: Implications for Relaxin-based Therapies

Dec. 15

Genetics and Genomics of Longitudinal Lung Function Patterns in Asthmatics

The 6-Minute-Walk Test as a Chronic Obstructive Pulmonary Disease Stratification Tool: Insights from the COPD Biomarker Qualification Consortium

Impact of 24/7 In-Hospital Intensivist Coverage on Outcomes in Pediatric Intensive Care: A Multicenter Study

Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study

Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage


ATS 2016 Full Registration