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MicroRNA-1 Regulates Tumor Growth

By Jadwiga A. Wedzicha, MD, editor, American Journal of Respiratory and Critical Care Medicine

Follow Dr. Wedzicha on Twitter @ATSBlueEditor

Lung Endothelial MicroRNA-1 Regulates Tumor Growth and Angiogenesis

MicroRNAs regulate gene expression and have been shown to be altered in malignancies. In their Dec. 1 American Journal of Respiratory and Critical Care Medicine paper, Asawari Korde and colleagues report on a series of experiments to examine the potential clinical significance of miR-1, a lung endothelial microRNA, in non-small cell lung cancer. The researchers found that in NSCLC patients miR-1 levels were lower in tumors than in cancer-free tissue and that these levels correlated to survival. In fact, they observed a strong trend towards an inverse correlation. MiR-1 levels were also lower in the endothelial cells isolated from the tumors and tumor-bearing lungs of a mouse model. Through vector-mediated delivery and transgenic over-expression of miR-1 in the mice, tumor burden and angiogenesis were decreased.

The researchers noted that recent efforts at personalizing cancer therapies have focused on the malignant cells themselves. Their study highlights the fact that there is “complex and multifaceted interaction between malignant cells and their microenvironment.”

AJRCCM Highlights

Dec. 1

Prenatal Nitrate Exposure and Childhood Asthma: Influence of Maternal Prenatal Stress and Fetal Sex

Signs of Gas Trapping in Normal Lung Density Regions in Smokers

Adverse Heart–Lung Interactions in Ventilator-induced Lung Injury

Effect of Obstructive Sleep Apnea Treatment on Renal Function in Patients with Cardiovascular Disease

Recommendations for a Standardized Pulmonary Function Report: An Official American Thoracic Society Technical Statement

Patient Education/Information Series: What is Sepsis?

Dec. 15

A Recombinant Fragment of Human Surfactant Protein D Suppresses Basophil Activation and T Helper Type 2 and B Cell Responses in Grass Pollen–induced Allergic Inflammation

A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (TRANSFORM)

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill

Maturation of the Infant Respiratory Microbiota, Environmental Drivers, and Health Consequences: A Prospective Cohort Study

Nocturnal Oximetry-based Evaluation of Habitually Snoring Children

AJRCCM Call for Papers ATS 2018

The AJRCCM is planning the journal issue to be published and distributed at the ATS 2018 International Conference, May 18‒23, in San Diego. Submissions are welcome from the global respiratory community on respiratory medicine, critical care, and sleep disorders. In particular, AJRCCM editors seek papers involving clinical trials, epidemiology, and clinical translational research. The deadline to submit is Dec. 15. Begin your manuscript submission.

All submissions should conform to the AJRCCM's formatting requirements, as outlined in the Instructions for Contributors. Be sure to mention the ATS Conference issue in your online submission cover letter. Contact Marc Bendian, mbendian@thoracic.org, with any questions.