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MDSCs in PH Associated with IPF

By Paul Schumacker, PhD, editor, American Journal of Respiratory Cell and Molecular Biology
Follow Dr. Schumacker on Twitter @ATSRedEditor

Myeloid-derived Suppressor Cells are Necessary for Development of Pulmonary Hypertension

In their February American Journal of Respiratory Cell and Molecular Biology article, Andrew J. Bryant, MD, and co-authors report for the first time that myeloid-derived suppressor cells (MDSCs) are necessary for the development of pulmonary hypertension in murine models of the disease. The researchers found MDSCs play a central role in “coordinating the inflammatory milieu contributing to vascular remodeling” and that in pulmonary fibrosis, trafficking to the lung of a granulocytic subset of MDSCs is increased. MDSCS express high levels of the chemokine receptor CXCR2.  By inhibiting CXCR2, the researchers found, vascular changes were attenuated. “Our study provides solid pre-clinical evidence for further study of CSCR2 inhibitors in prevention, and potentially treatment, of PH associated with IPF,” the authors conclude.

February Highlights

Translational Review: Noncoding RNAs, New Players in Pulmonary Medicine and Sarcoidosis

Translational Review: Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease:  Role of Cigarette Smoke Exposure

Myeloid-Derived Suppressor Cells are Necessary for Development of Pulmonary Hypertension

Long Non-Coding RNA LnRPT Is Regulated by PDGF-BB and Modulates Proliferation of Pulmonary Artery Smooth Muscle Cells

Twist1 in Hypoxia-Induced Pulmonary Hypertension through TGFβ-Smad Signaling

Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria

Multi-Tissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma