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Mild COPD, Exacerbations, and Lung Function Loss

February 1, 2017 at 12:03 am

By Jadwiga A. Wedzicha, MD, editor, American Journal of Respiratory and Critical Care Medicine

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Acute Exacerbations and Lung Function Loss in Smokers with and without Chronic Obstructive Pulmonary Disease

In the Feb. 1 American Journal of Respiratory and Critical Care Medicine, Mark T. Dransfield and colleagues report that among 2,000 participants enrolled in the COPDGene study, exacerbations are associated with accelerated lung function loss in subjects with established COPD. Over five years, the loss was greatest among participants classified as GOLD 1 patients: each exacerbation in this group was associated with an additional 23mL/year decline in FEV1.  In addition to this novel finding, the authors report that severe exacerbations also resulted in greater lung function decline. The study findings raise the possibility that preventing exacerbations in those with mild disease “could reduce the risk of developing severe COPD, an important hypothesis that should motivate randomized trials.”  Peter M. A. Calverley wrote an accompanying editorial.

AJRCCM Highlights

Feb. 1

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations

Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy

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SP110b Controls Host Immunity and Susceptibility to Tuberculosis


Feb. 15

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED

Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts

A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury

SH2 Domain–Containing Phosphatase Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis

MicroRNA-138 and MicroRNA-25 Downregulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype


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