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NIV and ARDS Severity, Mortality

January 13, 2017 at 5:00 pm

By Jadwiga A. Wedzicha, MD, editor, American Journal of Respiratory and Critical Care Medicine

Follow Dr. Wedzicha on Twitter @ATSBlueEditor

Noninvasive Ventilation of Patients with ARDS: Insights from the LUNG SAFE Study

In the Jan. 1 American Journal of Respiratory and Critical Care Medicine, Giacomo Bellani and an international group of researchers report on one of the largest observational studies of noninvasive ventilation of patients with acute respiratory distress syndrome. NIV may reduce complications related to endotracheal intubation and invasive mechanical ventilation, but the authors argue that current evidence supporting its use in ARDs patients is based on small studies.  Across more than 450 ICUs, the researchers found that 15 percent of 2,813 ARDS patients received NIV—a level of use that did not vary by disease severity. However, NIV failure occurred in half of patients with moderate and severe ARDS and more than one-third of the patients overall. Of particular concern, the authors write, “NIV was associated with a worse adjusted ICU mortality than invasive MV in patients in patients with a PaO2/FiO2 lower than 150 mmHg.”

AJRCCM Highlights

Jan. 1

Mortality Due to Respiratory Syncytial Virus: Burden and Risk Factors

The Role of Exercise in a Weight-Loss Program on Clinical Control in Obese Adults with Asthma

Effect of Nintedanib in Subgroups of Idiopathic Pulmonary Fibrosis by Diagnostic Criteria

Respiratory Muscle Strength as a Predictive Biomarker for Survival in Amyotrophic Lateral Sclerosis

Mortality Due to Respiratory Syncytial Virus: Burden and Risk Factors

An Official American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. Rehabilitation Protocols, Ventilator Liberation Protocols, and Cull Leak Tests

Jan. 15

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control

Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COSYCONET Study

Incidence, Predictors, and Outcomes of New-Onset Atrial Fibrillation in Critically Ill Patients with Sepsis: A Cohort Study

Evaluation of the Global Lung Initiative 2012 Reference Values for Spirometry in African Children

Resonance as the Mechanism of Daytime Periodic Breathing in Patients with Heart Failure

An Official American Thoracic Society Research Statement: Current Challenges Facing Research and Therapeutic Advances in Airway Remodeling. Executive Summary


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