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PLA2R1, a New Asthma Target?

December 19, 2016 at 4:27 pm

By Paul Schumacker, PhD, editor, American Journal of Respiratory Cell and Molecular Biology

Follow Dr. Schumacker on Twitter @ATSRedEditor

Identification of Epithelial Phospholipase A2 Receptor 1 (PLA2R1) as a Potential Target in Asthma

In their December American Journal of Respiratory Cell and Molecular Biology article, James D. Nolin and colleagues identify a novel c-type lectin receptor called PLA2R1 that was overexpressed in the asthma patients they studied. Then, using a mouse model deficient in the PLA2R1 gene, the researchers found “a marked increase” in airway hyperresponsiveness. “The most plausible explanation for these findings,” the researchers wrote, “is the increase in the peribronchial area, increased airway permeability, and increased degranulation of eosinophils in the airways” they found in mice without the PLA2R1 gene. Together, these results suggest that PLA2R1 is a regulator of allergic inflammation and a potential target for asthma therapy.

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