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RCT of EBV Therapy in Homogenous Emphysema

November 10, 2016 at 2:24 pm

By Jadwiga A. Wedzicha, MD, editor, American Journal of Respiratory and Critical Care Medicine

Follow Dr. Wedzicha on Twitter @ATSBlueEditor

Endobronchial Valve Therapy in Patients with Homogeneous Emphysema: Results from the IMPACT Study

In the Nov. 1 American Journal of Respiratory and Critical Care Medicine, Arschang Valipour and his European colleagues report on the first randomized controlled trial of endobronchial valve therapy for homogeneous emphysema. The 43 patients who were implanted with valves (median number: 4) demonstrated “statistically and clinically significant improvements in lung function, exercise capacity, and quality of life with EBV therapy” compared to controls. The intervention, however, also resulted in more serious complications, primarily pneumothoraxes. The authors conclude that the “benefits of this therapy need to be weighed carefully against the associated risk.”

AJRCCM Highlights

Nov. 1

Improving Appropriate Neurological Prognostication after Cardiac Arrest: A Stepped-Wedge Cluster Randomized Controlled Trial

Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations

Nasopharyngeal Microbiota, Host Transcriptome, and Disease Severity in Children with Respiratory Syncytial Virus Infection

Infectiousness of HIV-Seropositive Tuberculosis Patients in a High-Burden African Setting

Nov. 15

Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung: Implications for NTHi Infection

Progranulin Plays a Central Role in Host Defense during Sepsis by Promoting Macrophage Recruitment

Plasma Surfactant Protein-D, Matrix Metalloproteinase-7, and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis from Other Idiopathic Interstitial Pneumonias

Airway Microbiota Determines Innate Cell Inflammatory or Tissue Remodeling Profiles in Lung Transplantation

Continuous Positive Airway Pressure Improves Quality of Life in Women with Obstructive Sleep Apnea: A Randomized Controlled Trial


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