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Straight Line: Airflow Restriction and Lung CA

March 2, 2017 at 11:36 am

By John Hansen-Flaschen, MD, editor, Annals of the American Thoracic Society

Follow Dr. Hansen-Flaschen on Twitter @AnnalsATSEditor

Reduced Expiratory Flow Rate among Heavy Smokers Increases Lung Cancer Risk: Results from the NLST-ACRIN Cohort (N=18, 714)

Is the relationship between airflow limitation and lung cancer risk linear? After reviewing a large prospective study of older heavy smokers from the National Lung Screening Trial, an international group of researchers reporting in the March Annals of the American Thoracic Society say it is—and strongly so. Using Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades, the researchers report that among those with no airflow restriction, lung cancer incidence was 3.78/1000 person years. As airflow limitation grew more severe, cancer incidence increased: GOLD 1 6.27/1000 person years, GOLD 2 7.86/1000 person years, GOLD 3 10.71/1000 person years, and GOLD 4 13.25/1000 person years. The researchers write that their findings “support the routine use of spirometry in asymptomatic adult smokers, especially those otherwise eligible for CT screening.”

March Highlights

House Dust Endotoxin Levels Are Associated with Adult Asthma in a U.S. Farming Population

Sinus Computed Tomographic Findings in Adult Smoking and Non-Smoking Asthmatics: Analysis of Clinical Indices and Biomarkers

Therapeutic Laryngoscopy during Exercise for Treatment of Refractory Exercise-induced Laryngeal Obstruction: A Personal Experience


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