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Study Identifies Genome-level OSA Associations

October 3, 2016 at 12:03 am

By Jadwiga A. Wedzicha, MD, editor, American Journal of Respiratory and Critical Care Medicine

Follow Dr. Wedzicha on Twitter @ATSBlueEditor

Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans

In the Oct. 1 American Journal of Respiratory and Critical Care Medicine, Brian E. Cade and colleagues report on a meta-analysis of more than 12,000 Hispanic/Latinos to determine if obstructive sleep apnea (OSA) in this population has a genetic component. The study identified three genetic loci that have a statistically significant association, as well as others that are “suggestively associated” with Apnea Hypopnea Index (AHI), average oxyhemoglobin saturation, and duration of an apnea/hypopnea event. The study represents the largest genetic analysis of OSA conducted in any population. Its novel use of measurements of oxygen saturation and respiratory event duration in addition to AHI, the authors write, “may facilitate the genetic dissection of OSA.”

AJRCCM Highlights

Oct. 1

A Novel CD4+ T Cell–dependent Murine Model of Pneumocystis-driven Asthma-like Pathology

The RECOVER Program: Disability Risk Groups and One-Year Outcome after 7 or More Days of Mechanical Ventilation

Physical Activity, Air Pollution, and the Risk of Asthma and Chronic Obstructive Pulmonary Disease

HIPPO–Integrin Linked Kinase Cross-Talk Controls Self-sustaining Proliferation and Survival in Pulmonary Hypertension

Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension

Oct. 15

Fetal Phagocytes Take Up Allergens to Initiate Th2 Immunity and Facilitate Allergic Airway Responses

Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

Heterogeneity in the Effects of Reward- and Deposit-based Financial Incentives on Smoking Cessation

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