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Vit D May Help Prevent VAP

October 3, 2016 at 12:02 am

By Paul Schumacker, PhD, editor, American Journal of Respiratory Cell and Molecular Biology

Follow Dr. Schumacker on Twitter @ATSRedEditor

Ascorbic Acid Attenuates Hyperoxia-Compromised Host Defense Against Pulmonary Bacterial Infection

Could ascorbic acid help prevent ventilator-associated pneumonia (VAP)? In their October American Journal of Respiratory Cell and Molecular Biology article, Vivek S. Patela and colleagues report on a murine study that suggests the answer may be yes. The researchers found that ascorbic acid “protects against hyperoxia-induced lung injury and enhances innate immunity” against infection by Pseumdomonas aeruginosa, a multidrug-resistant bacterium. The study demonstrated that ascorbic acid significantly preserved macrophage phagocytic function, decreased oxidative stress in culture macrophages, and reduced extracellular high mobility group box protein B1 (HMGB1) levels in vitro and in vivo. The authors conclude: “Our findings suggest that supplementation with ascorbic acid during supportive oxygen therapy may be an effective intervention to attenuate or prevent” VAP.

October Highlights

Alternative Macrophage Activation Is Increased in Asthma

Rhinovirus Delays Cell Repolarization in a Model of Injured/Regenerating Human Airway Epithelium

Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response from Type 1 to Type 2

Lung-Restricted Antibodies Mediate Primary Graft Dysfunction and Prevent Allotolerance after Murine Lung Transplantation

Formaldehyde Induces Rho-Associated Kinase Activity to Evoke Airway Hyperresponsiveness

Cigarette Smoke Extract–Exposed Methicillin-Resistant Staphylococcus aureus Regulates Leukocyte Function for Pulmonary Persistence


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